Smart 'Band-Aid' senses skin temp, dispenses medicine: Page 2 of 2

December 08, 2015 //By Paul Buckley
Smart 'Band-Aid' senses skin temp, dispenses medicine
Engineers at MIT (Cambridge, MA) have designed a 'smart wound dressing' that is not only capable of releasing medicine in response to changes in skin temperature but which can also indicate - by lighting up - if the medicine is running low.

In the new study, the researchers applied their techniques to demonstrate several uses for the hydrogel, including encapsulating a titanium wire to form a transparent, stretchable conductor. In experiments the encapsulated wire was stretched multiple times and found to maintain constant electrical conductivity.

Zhao also created an array of LED lights embedded in a sheet of hydrogel. When attached to different regions of the body, the array continued working, even when stretched across highly deformable areas such as the knee and elbow.

Finally, the group embedded various electronic components within a sheet of hydrogel to create a 'smart wound dressing,' comprising regularly spaced temperature sensors and tiny drug reservoirs. The researchers also created pathways for drugs to flow through the hydrogel, by either inserting patterned tubes or drilling tiny holes through the matrix. They placed the dressing over various regions of the body and found that even when highly stretched the dressing continued to monitor skin temperature and release drugs according to the sensor readings.

According to co-author of the study, Hyunwoo Yuk, an immediate application of the technology may be as a stretchable, on-demand treatment for burns or other skin conditions.

"It's a very versatile matrix," says Yuk. "The unique capability here is when a sensor senses something different, like an abnormal increase in temperature, the device can on demand release drugs to that specific location and select a specific drug from one of the reservoirs, which can diffuse in the hydrogel matrix for sustained release over time."

Delving deeper, Zhao envisions hydrogel to be an ideal, biocompatible vehicle for delivering electronics inside the body. Zhao is currently exploring hydrogel's potential as a carrier for glucose sensors as well as neural probes. Conventional glucose sensors, implanted in the body, typically spark a foreign-body response from the immune system, which covers the sensors with dense fibers, requiring the sensors to be replaced often.

While various hydrogels have been used to coat glucose sensors and prevent such a reaction, the hydrogels are brittle and can detach easily with motion. According to Zhao, the hydrogel-sensor system his group is developing would likely be robust and effective over long periods. He says a similar case might be made for neural probes.

"Currently, researchers are trying different soft materials to achieve long-term biocompatibility of neural devices. With collaborators, we are proposing to use robust hydrogel as an ideal material for neural devices, because the hydrogel can be designed to possess similar mechanical and physiological properties as the brain."

For more, see the paper in the journal Advanced Materials: "Stretchable Hydrogel Electronics and Devices."

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